There are a few of us with X45's and X36's. I thought I'd start this thread and put some helpful information. First some files. I've been communicating with Saitek tech support, and they have given me this as the latest driver to support the X45, stating: ...generic drivers for 64 bit version operating system that could also work on Windows 10 64 bit, but we could not guarantee. ftp://ftp.saitek.com/pub/software/full/Saitek_X45_Flight_Controller_SD6_64.exe The Saitek SST Profile Editor software can add additional functionality to the joystick. but this one does. It says it's for Saitek Cyborg V3 PAD ,But it will work with the X45, and I suppose other legacy Saitek controllers. ftp://ftp.saitek.com/pub/software/full/SST_Software_64_6_6_6_9.exe The SC Joystick Mapper tool comes in handy when trying to put together a profile... Check it out. It has been updated for SC 2.5 https://github.com/SCToolsfactory/SCJMapper-V2/releases A helpful tip I've run across is that the stick should be plugged into a USB 2.0 slot to avoid crashing during use. I've been told that this goes also for the X52. I should have a profile for you to download, soon. If you have one that works better, please post it here. Manual for the SST Profile Editor. There is a link on that page for advanced programming. http://www.saitek.com/manuals/st/SST_Manual_En.html Found a printable form for the X45/X35 for button assignments. http://i.imgur.com/fkDNacV.jpg I've created an editable form from it so that you can edit field entries in Acrobat or your preferred PDF viewer, It has the default button assignments as displayed in most games. Feel free to download, print out, edit and share. X45 Blank Profile Map With System Button Assignments https://mega.nz/#!PswgQQJB!gHgzWJ8BW3SVgvbN_pSUSyZEFba9f6_fK8bHwfy6u3E On another note: if you want to utilize the mode switches, you will have to program them in the SST. I've created two profiles in the SSTsoftware, that can utilize the mode keys, using macros, to switch between keybind layouts in SC. It basically allows you to switch profiles without having to take your hands off the controls, in no time at all. x45 mode switch files https://mega.nz/#!fkAF1YAZ!CbmHGCQb2LO5sSPkqJJQKslwJCQWNQAPqdfmEB2lrz0 Layouts and Profiles Basic Layout for the X45: https://mega.nz/#!m1QngLhK!zlncCGCDfqym3R48gmuzVlBmqAeLk6iCjTCuTyt54qg This is a basic layout loosely based on the stock x52 layout found in SC. The zip includes a printable button map, SST profile editor files that have my layout switching macro pre-programmed, and 9 key bind layout files for SC, all of which are identical but can and should be edited. Drivers And Profiles Zip https://mega.nz/#!n1xw0YoC!pkm2TTyXiO8PQce1E86VHNmaJe38L8HA7w7McYK48a4 With Logitech's acquisition of Saitek, I've decided it might be prudent to provide a zip file with the drivers and software, There are instructions in a readme file on how to install them. Saitek says that they no longer support the x-45, so I don't think that this is illegal distribution. If it is, let me know and I will take off the link. Edit: Since I made this thread, Saitek/Logitech has made a page for all of their products, including legacy support. The files linked there are the same ones on this thread. http://saitek.com/uk/down/drivers.php